患者女,65岁。因两眼干痛,视物不清5年、加重2年,于1989年2月24日入院。病初曾出现怕热、多汗、心悸、乏力。两年前曾用昆布、海藻等中草药2个月,症状好转,但出现两眼流泪、畏光、灼痛、视物模糊,眼睑不能闭合。双下肢皮肤干燥瘙痒、皮疹,随后形成结节并增大,互相融合,皮肤变厚,同时趾端肥大、变粗呈杵状。既往史无特殊。 Female patient, 65 years old. Due to dry eye pain, blurred vision for 5 years, increased 2 years, on February 24, 1989 admission. At the beginning of the disease there was fear of heat, sweating, palpitations, fatigue. Two years ago with kelp, seaweed and other herbs 2 months, the symptoms improved, but there are tears, photophobia, burning, blurred vision, eyelids can not be closed. Both legs dry skin itching, rash, and then the formation of nodules and increase, mutual integration, skin thickening, while toe hypertrophy, thick clubbing. No previous history.