In order to observe the therapeutic effects of the brain-resuscitation acupuncture method for post wind-stroke mental depression, 90 such cases were randomly divided into two groups, each consisting of 45 cases. For the treatment group, the brain-resuscitation acupuncture method was adopted, with Neiguan (PC 6), Renzhong (GV 26), Sanyinjiao (SP 6), Baihui (GV 20), and Shenmen (HT 7) selected as the main points. For the control group, oral medication of Fluoxetine was prescribed. Therapeutic effects and changes in the HAMD integrals of the two groups were observed. The total effective rate in the treatment group was 77.7%, and that in the control group was 75.1%, showing no significant difference between the two groups (P＞0.05). The average effect starting time of the treatment group was 11.58±4.89 days, while that of the control group was 15.96±6.50 days, showing a significant difference between the two groups (P＜0.05). It can be concluded that for the post wind-stroke mental depression, the brain-resuscitation acupuncturemethod may show a good and quicker therapeutic effect with no side effects as compared with pharmacotherapy.