骨骼肌的主要功能是控制身体活动和维持身体姿势,在骨骼肌生长发育过程中,不同的代谢环境会使骨骼肌产生不同的代谢应激与适应,因此骨骼肌有很强的适应能力[1]。近年来越来越多的研究发现骨骼肌对其他器官的代谢活动起到重要作用,特别是由于失重、癌症和衰老等原因造成的骨骼肌长期失用而导致的骨骼肌萎缩。骨骼肌萎缩参与了很多代谢性疾病的发生,如肥胖、糖尿病等[2]。研究显示不同身体活动干预可预防 Skeletal muscle’s main function is to control physical activity and maintain body posture. In the process of skeletal muscle growth and development, different metabolic environment will produce different metabolic stress and adaptation of skeletal muscle, so skeletal muscle has strong adaptability [1 ]. In recent years, more and more studies have found that skeletal muscle plays an important role in metabolic activity of other organs, especially skeletal muscle atrophy caused by long-term skeletal muscle loss due to weight loss, cancer and aging. Skeletal muscle atrophy involved in many metabolic diseases, such as obesity, diabetes, etc. [2]. Research shows that different physical activity interventions are preventable