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一、白血病治疗的新阶段1964年 Wintrobe 曾指出急性粒细胞白血病的预后“基本病程只有6个月”,强的松及6-巯基嘌呤应用后,病情与预后虽有所改善,但 Gunz 曾提到6-巯基嘌呤仅能使1/10～2/10病例缓解。以后新药不断增加,1980年蒽环类抗癌药物的问世,治疗效果又推进丁一步。有人预言,“急性白血病已从姑息疗法阶段转入根治的新阶段”。白血病疗效进步的关键是化学药物治疗策略的改进,以下的数据即可说明。1、儿童急性淋巴细胞白血病5年存活率为50%,且少部分能治愈。2、各学者对成人急性粒细胞白血病的疗效指标,列举如下:
A new phase of leukemia treatment Wintrobe pointed out in 1964 that the prognosis of acute myeloid leukemia “basic course of only 6 months,” the application of prednisone and 6-mercaptopurine, although the disease and prognosis have improved, but Gunz had mentioned To 6 - mercaptopurine only make 1/10 ~ 2/10 cases ease. After the new drugs continue to increase in 1980, the advent of anthracycline anti-cancer drugs, the treatment effect and promote one step further. Some people predict that “acute leukemia has changed from the palliative phase of treatment to a new phase of radicalization.” The key to the improvement of leukemia efficacy is the improvement of the chemotherapeutic strategy. The following data can be explained. 1, 5-year survival rate of children with acute lymphoblastic leukemia is 50%, and a small part can be cured. 2, the scholars of adult acute myeloid leukemia efficacy index, as follows: