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串珠镰刀菌(Fusarium moniliforme C)是一种在粮食中较常见的真菌,在食管癌高发区林县玉米中,其污染率达49.6％。实验表明该菌的代谢物有致突变作用和致癌作用。1984年我们从林县串珠镰刀菌培养物中分离得到强致突变物镰刀菌素C(Fusarin c,FC)。Weibe和Bjeldanes首先报道从Fusarium moniliforme中分离出FC。以后证明FC不仅对细菌有致突变作用,而且对哺乳类动物细胞也有明显致突变作用。在林县田间玉米中存在有FC。为研究其与食管癌病因学的关系,我们应用TLC和HPLC等方法检测其在环境中的分布,本文报道化学测定微量FC方法的建立。
Fusarium moniliforme C is one of the more common fungi found in grain. In the corn of Linxian County, a high-risk area of esophageal cancer, the contamination rate is 49.6%. Experiments show that the metabolites of the bacteria have mutagenic and carcinogenic effects. In 1984, we isolated the strong mutagenesis Fusarin c (FC) from the culture of Fusarium moniliforme in Linxian county. Weibe and Bjeldanes first reported the isolation of FC from Fusarium moniliforme. It was later shown that FC not only has mutagenic effects on bacteria, but also has significant mutagenic effects on mammalian cells. There is FC in field corn in Lin County. In order to study its relationship with the etiology of esophageal cancer, we used TLC and HPLC to detect its distribution in the environment. This paper reports the establishment of a chemical method for the determination of micro FC.