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目的:分析δ阿片受体激动剂(DADLE)对大鼠急性全脑缺血再灌注继发肺损伤的作用。方法:选取30只大鼠,随机分为DADLE组、假手术组与模型组,使用改良后血管降低血压阻断,构建全脑缺血的再灌注模型,在大鼠右侧的股动脉提取血液,对氧分压(Pa O2)进行测定,然后计算出氧合指数(Pao2/Fi O2)。结果:DADLE组能够提高肺组织中超氧化物歧化酶(SOD)活性,降低丙二醛(MDA)的浓度,和模型组相比,差异具有统计学意义(P<0.05);DADLE组的Pa O2、Pa O2/Fi O2指数有升高的趋势,和模型组相比,差异具有统计学意义(P<0.05)。结论:DADLE可以减轻大鼠肺损伤,有保护作用,可以提高大鼠肺组织中的SOD活性,降低MDA的浓度。
Objective: To analyze the effect of δ opioid receptor agonist (DADLE) on lung injury secondary to acute global cerebral ischemia and reperfusion in rats. Methods: Thirty rats were selected and randomly divided into DADLE group, sham operation group and model group. Blood vessel was used to reduce the occlusion of blood pressure to construct a model of reperfusion after global ischemia. Blood was collected from the right femoral artery , The oxygen partial pressure (Pa O2) was measured, and then calculate the oxygenation index (Pao2 / Fi O2). Results: Compared with model group, DADLE group increased the activity of superoxide dismutase (SOD) and the concentration of malondialdehyde (MDA) in lung tissue. The difference was statistically significant (P <0.05) , Pa O2 / Fi O2 index had an increasing trend, compared with the model group, the difference was statistically significant (P <0.05). Conclusion: DADLE can attenuate lung injury in rats and has protective effects. It can increase SOD activity in lung tissue and decrease the concentration of MDA in rats.