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在制备水溶性硫辛酸酯封端的甲氧基聚乙二醇-聚己内酯嵌段共聚物(MPEG-PCL-ALA)单层包覆金纳米粒子的基础上,在水溶液中,利用α-环糊精(α-CD)与单层包覆金纳米粒子的包合作用构建杂化超分子水凝胶.透射电子显微(TEM)照片显示,金纳米粒子的尺寸为6～8 nm.X射线衍射测试表明,所制备的水凝胶中含有α-环糊精与MPEG-PCL嵌段共聚物包合形成的多聚准轮烷的特征衍射峰(2θ=19.7°).紫外-可见吸收光谱显示,单层包覆金纳米粒子的水溶液及其与α-CD包合形成的水凝胶在525 nm处均出现表面等离子共振吸收峰,单层包覆金纳米粒子溶液存放3个月后,其表面等离子共振吸收峰未发生明显红移,表明单层包覆金纳米粒子的水溶液具有较好的稳定性.
In the preparation of water-soluble lipoic acid capped methoxy polyethylene glycol - polycaprolactone block copolymer (MPEG-PCL-ALA) monolayer coated gold nanoparticles, in aqueous solution, the use of α - Cyclodextrin (α-CD) with single-coated gold nanoparticles to construct hybrid superamolecular hydrogel. Transmission electron microscopy (TEM) photographs show that the size of the gold nanoparticles is 6 ~ 8 nm The results of X-ray diffractometry showed that the prepared hydrogels had the characteristic diffraction peak (2θ = 19.7 °) of poly-piroctane formed by inclusion of α-cyclodextrin and MPEG-PCL block copolymer.UV- The visible absorption spectra showed that the surface plasmon resonance absorption peak appears at 525 nm in the aqueous solution of single-layer coated gold nanoparticles and the hydrogel formed by the inclusion of α-CD. The single-layer coated gold nanoparticle solution stores 3 After month, the surface plasmon resonance absorption peak did not show a significant red shift, indicating that the monolayer coated gold nanoparticles aqueous solution has good stability.