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环氧合酶(COX)是催化花生四烯酸(AA)合成各种前列腺素(PG)的关键酶,参与神经细胞的分化和成熟以及神经突触的可塑性,能够影响神经递质释放、调节脑血流、介导脊髓疼痛机制和机体的发热反应等,通过复杂的机制参与兴奋性神经元的突触传递、中枢神经系统感染、各种脑损伤(颅脑创伤、脑血管疾病和癫等)及神经元退行性疾病[阿尔茨海默病(AD)、帕金森病(PD)等]的病理过程[1]。环氧合酶2(COX-2)被认
Cyclooxygenase (COX) is a key enzyme catalyzing the synthesis of various prostaglandins (PGs) by arachidonic acid (AA). It participates in the differentiation and maturation of nerve cells and the plasticity of synapses, and can affect the release of neurotransmitters, Cerebral blood flow, mediating spinal pain and the body’s fever response, through a complex mechanism involved in the synaptic transmission of excitatory neurons, central nervous system infections, various brain injuries (traumatic brain injury, cerebrovascular disease and epilepsy ) And neurodegenerative diseases [Alzheimer’s disease (AD), Parkinson’s disease (PD), etc.] pathological process [1]. Cyclooxygenase 2 (COX-2) is recognized