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本文为了解毛冬青甲素对心传导系统的作用,进而探讨其抗心律失常的作用机理。实验将家兔分成两组,正常对照组(10只)和用药组(10只),用RM—6000四导生理记录仪同步描记希氏束电图(HBE)、心电图(ECG)和血压。本实验统计学处理后,结果表明:用药组注射毛冬青甲素后HBE的A—H间期为63.5±6.00ms,与静注前(47.3+8.22ms)比较P<0.001,与对照组比较P<0.001;注药后5～10分钟,心率248±13.0降至203±13.7次/分(P<0.05);多数家兔注药后5～10分钟收缩压平均下降2.85kPa(P<0.05),舒张压平均下降1.50kPa(P<0.05)。提示毛冬青甲素能使房室传导时间延迟,降低心传导系统的兴奋性,从而消除了异位搏动以及使心率减慢,血压下降,产生抗心律失常的效应。
In order to understand the effect of Mao Dongqing A on the cardiac conduction system, this article discusses the mechanism of its antiarrhythmic effect. The rabbits were divided into two groups. The normal control group (10) and the medication group (10) were used to simultaneously record the HBE, ECG, and blood pressure with a RM-6000 4-conductor physiological recorder. After statistical analysis of this experiment, the results showed that the AH interval of HBE was 63.5±6.00ms after injecting oxydactin in the drug group, compared with (47.3+8.22ms) before intravenous injection, P<0.001, compared with the control group. P<0.001; 5 to 10 minutes after injection, the heart rate decreased from 248±13.0 to 203±13.7 beats/min (P<0.05); the mean systolic blood pressure decreased by 2.85 kPa in most rabbits 5 to 10 minutes after injection (P<0.05). The average diastolic pressure decreased by 1.50 kPa (P<0.05). Tip Mao Dongqing A can delay the atrioventricular conduction time, reduce the excitability of the heart conduction system, thereby eliminating the ectopic beats and slowing down the heart rate, blood pressure, anti-arrhythmic effects.