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目的 为了研究肥大细胞及其脱颗粒在炎症性肠病中的致病作用。方法 采用改良甲苯胺蓝法染色观察了3 0例溃疡性结肠炎 (UC)、12例克隆病 (CD)和 12例感染性结肠炎标本中肥大细胞及脱颗粒情况。结果 本组炎症性肠病标本 ,HE染色皆呈急性活动性炎症。UC患者肠粘膜中MC总数及其脱颗粒率较低 ,CD患者肠粘膜内的MC总数最高其脱颗粒率也较高 ,感染性肠炎肠粘膜内MC总数居中 ,但其脱颗粒率最高 ,三者之间有显著差异P <0 .0 5～ 0 .0 1)。结论 MC及其脱颗粒参与了肠病的致病过程。
Objective To investigate the pathogenic role of mast cells and their degranulation in inflammatory bowel disease. Methods The mast cells and degranulation in 30 specimens of ulcerative colitis (UC), 12 specimens of Crohn’s disease (CD) and 12 specimens of infectious colitis were observed by modified toluidine blue staining. Results of this group of inflammatory bowel disease specimens, HE staining showed acute active inflammation. The total number of MC in the intestinal mucosa of UC patients and the rate of degranulation were lower. The total number of MC in the intestinal mucosa of CD patients was higher than that in CD patients. The total number of MCs in the intestinal mucosa of infectious enteritis was the highest, There was a significant difference between P <0. 05 ~ 0. 01). Conclusion MC and its degranulation are involved in the pathogenic process of enteropathy.