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1例86岁男性患者因疑似焦虑症,给予氟哌噻吨美利曲辛1片,1次/d口服。用药后逐渐出现精神萎靡、嗜睡、乏力、进食减少。第19天出现进食恶心。第28天进展为进食吞咽困难,无法站立行走,反应迟钝。血电解质检查:钾4.0 mmol/L,钠121mmol/L,氯84 mmol/L。诊断低钠、低氯血症。氟哌噻吨美利曲辛减至1/2片、1次/d。次日患者精神及进食状态明显好转。1周后氟哌噻吨美利曲辛减至1/4片、1次/d。2周后停用氟哌噻吨美利曲辛。患者恢复正常。复查血电解质:钾4.3 mmol/L,钠135 mmol/L,氯98 mmol/L。
A 86-year-old male patient was given oral flumethoxil, melitracen 1 tablet once daily because of suspected anxiety disorder. After treatment gradually apathetic, lethargy, fatigue, eating less. The first nine days of eating nausea. Progress on the 28th to eat dysphagia, unable to walk, unresponsive. Blood electrolytes: potassium 4.0 mmol / L, sodium 121 mmol / L, chlorine 84 mmol / L. Diagnosis of hyponatremia, hyponatremia. Flupentixol MTX reduced to 1/2, 1 / d. The next day the patient’s mental status and eating significantly improved. After 1 week, flupentixol and melitracen reduced to 1/4, 1 / d. Halopethixol was discontinued after 2 weeks. The patient returned to normal. Review of blood electrolytes: potassium 4.3 mmol / L, sodium 135 mmol / L, chlorine 98 mmol / L.