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5名健康志愿者(4男,1孕妇)口服含有100mg冻干灭活变形链球菌的胶囊。第1次免疫连续口服10天,每日定时服用;第2次免疫连续口服7天,孕妇产前10天开始口服。每周或每2个月收集唾液、泪液、初乳或乳液、全血和齿斑物,用ELISA和放射免疫扩散法检测。结果表明,第1次免疫后,唾液和泪液中的抗变形链球菌菌体分泌性免疫球蛋白A(sIgA)抗体水平比免疫前明显提高。初乳或乳液中的IgA抗体水平也相应地明显增加。约在初免后20天,抗体水平达到高峰,40天后又降到免疫前水平。初免80天后,进行第2次免疫。sIgA抗体水平比初免后升高更快、
Five healthy volunteers (4 males, 1 pregnant woman) orally contained 100 mg capsules of lyophilised inactivated Streptococcus mutans. The first immunization continuous oral administration of 10 days, daily time taken; the second immunization oral continuous 7 days, 10 days prenatal pregnant women began oral administration. Saliva, tear, colostrum or emulsion, whole blood and tooth stains were collected weekly or every 2 months and tested by ELISA and radioimmunoassay. The results showed that after the first immunization, the levels of sIgA antibodies against S. mutans in saliva and tear were significantly higher than those before immunization. The level of IgA antibody in colostrum or milk is also correspondingly significantly increased. About 20 days after the first immunization, the antibody level peaked and dropped to the pre-immunization level 40 days later. 80 days after the first immunization, the second immunization. sIgA antibody levels increased faster than after priming,