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据第四次遗传学分析讨论会报道,人类乳腺癌的遗传分析,与对其它许多常见病的研究一样,都面临几个问题,这包括,抽样的方式,遗传的异质性以及基因-环境的相互作用等问题。在200个丹麦人家谱中,乳腺癌的家族遗传不能用孟德尔的单一显性基因的分离来解释,这是因为,在混合模式下检测出的主要结果完全排除了孟德尔遗传。建议用一种较复杂的遗传机制或遗传异质性来解释,或用两者一起来解释。以前在统一的混合模式下进行分离分析,采用指示者的方略,这种方略需要将家系分拆成其组分即核心家庭,并要引入指示
According to the Fourth Genetic Analysis Symposium, genetic analysis of human breast cancer faces several issues as many other common diseases include sampling, genetic heterogeneity, and genetic-environmental The interaction and other issues. In the 200 Danish pedigree, the familial inheritance of breast cancer can not be explained by the separation of Mendelian single dominant genes, since the main result detected in mixed mode completely precludes Mendelian inheritance. Proposed to use a more complex genetic mechanism or genetic heterogeneity to explain, or both together to explain. In the past, the separation analysis under the unified mixed model adopted the strategy of the indicator person. This strategy required that the family be split into its components, namely the nuclear family, and the introduction of instructions