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应用实时超声技术检测29例肝硬化患者及15名正常人的胃运动功能,并以放射免疫法检测空腹血浆胃动素、血清雌二醇和孕酮浓度。结果:与对照组相比,肝硬化组胃半排空时间、胃全排空时间明显延长,胃窦收缩频率显著减慢。肝硬化组血浆胃动素浓度明显高于对照组,血清雌二醇浓度均在正常范围内,7例男性病人血清孕酮明显升高。结果表明:肝硬化病人存在胃运动功能障碍,推测这种障碍与肝硬化病人胃对胃动素的敏感性下降有关,部分病人还可能与孕酮代谢紊乱有关。
The gastric motor function of 29 patients with cirrhosis and 15 normal persons was detected by real-time ultrasound. The concentrations of fasting plasma motilin, serum estradiol and progesterone were detected by radioimmunoassay. Results: Compared with the control group, the gastric half emptying time, gastric emptying time significantly prolonged and the frequency of gastric antrum contraction significantly slowed down. Plasma concentrations of motilin in cirrhosis group were significantly higher than those in control group, serum estradiol concentrations were in the normal range, serum progesterone levels were significantly increased in 7 male patients. The results showed that: gastric motility disorders exist in patients with cirrhosis, speculated that this disorder and liver cirrhosis of patients with decreased sensitivity to motilin, and some patients may also be related to metabolic disorders progesterone.