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目的探讨上皮细胞钙黏蛋白(E-Cadherin)、尿激酶型纤溶酶原激活剂(uPA)表达与乳腺癌的浸润、淋巴结转移的关系。方法采用免疫组织化学链霉菌抗生物素蛋白-过氧化物酶连接法对乳腺纤维腺瘤、乳腺腺病和乳腺癌各40例蜡块中E-Cadherin、uPA表达进行研究。结果乳腺纤维腺瘤、腺病和乳腺癌中E-Cadherin阳性率分别为85.0%、82.5%和20.0%,三者差异有统计学意义(P<0.05);E-Cadherin表达阴性患者淋巴结转移率(90.6%)高于E-Cadherin表达阳性者(25.0%),差异有统计学意义(P<0.01)。uPA在乳腺纤维腺瘤、腺病均呈阴性表达,在乳腺癌中的阳性率为60.0%,三者差异有统计学意义(P<0.05);uPA表达阳性患者淋巴结转移率(88.5%)显著高于阴性者(50.0%),两者的表达差异有统计学意义(P<0.05)。结论 E-Cadherin和uPA的表达与乳腺癌的浸润转移密切相关,同步检测其在乳腺癌组织中的表达并综合分析二者之间的关系,对评价乳腺癌细胞的侵袭转移能力及预后判断具有一定价值。uPA在乳腺癌中表达率较高,而且和乳腺癌的生物学特性有关,它对提示预后和开展靶向治疗有指导意义。
Objective To investigate the relationship between the expression of E-cadherin, urokinase-type plasminogen activator (uPA) and the infiltration and lymph node metastasis of breast cancer. Methods The expression of E-Cadherin and uPA in 40 cases of breast fibroadenoma, breast adenosis and breast cancer were studied by immunohistochemical streptavidin-peroxidase ligation. Results The positive rates of E-Cadherin in breast fibroadenoma, adenosis and breast cancer were 85.0%, 82.5% and 20.0%, respectively (P <0.05). The rates of lymph node metastasis in patients with negative E-Cadherin expression (90.6%) was higher than that of E-Cadherin (25.0%), the difference was statistically significant (P <0.01). The positive rate of uPA in breast fibroadenoma and adenosis was 60.0% in breast fibroadenoma, the difference was statistically significant (P <0.05). The rate of lymph node metastasis (88.5%) in uPA positive patients was significantly Higher than negative (50.0%), the difference was statistically significant (P <0.05). Conclusions The expression of E-Cadherin and uPA is closely related to the infiltration and metastasis of breast cancer. The expression of E-Cadherin and uPA in breast cancer is detected synchronously, and the relationship between E-Cadherin and uPA expression is analyzed. The evaluation of invasion and metastasis and prognosis of breast cancer cells A certain value. The expression of uPA in breast cancer is high, and it is related to the biological characteristics of breast cancer. It is instructive to suggest the prognosis and carry out targeted therapy.