Over the past decade,comprehensive sequencing efforts have revealed signatures of cancer-related genes,such as driver and passenger genes,oncogenes,and tumor suppressor genes (TSGs) [1].These signatures offer a means of defining cancer at the molecular level and increase our understanding of cancers.However,current methods to reveal these signatures always explore the recurrence of mutated genes in a large cancer population,consuming a lot of time and money on sample collection,sequencing and validation,further generating large amounts of data to analyze [2].We wonder whether these signatures could be recovered from other aspects.Owing to a series of mutations from benign to malignant lesions,extensive genetic variations exist within individual tumors.During this process,driver genes provide a selective growth advantage to the cells they reside in.