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提要目的:探讨抗精神病药对海马γ氨基了酸(GABA)能抑制的影响。方法:利用离体海马脑片技术,采用逆一顺向双脉冲抑制和顺向双脉冲易化方式,观察20μmoL/L氟哌啶醇、100μmoL/L舒必利在双脉冲间隔(IPI)15-50ms对大鼠海马脑片CA1区双脉冲抑制和易化的影响。结果:氟哌啶
Abstract Objective: To investigate the effect of antipsychotics on the inhibition of γ-aminobutyric acid (GABA) in the hippocampus. Methods: The isolated hippocampal slice technique was used to observe the inhibitory effect of 20 μmol / L haloperidol and 100 μmol / L sulpiride at 15-50 ms intervals at IPI Effect of Double Pulse Suppression and Facilitation in CA1 Area of Rat Hippocampal Slices. Results: Droperidol