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NO是一种简单而不稳定的自由基气体,很多细胞均有合成NO的酶,自80年代研究才开始认识NO的生物学作用,10余年的研究表明,NO可作为介质、信使或细胞功能调节因子,参与机体许多生理和病理过程,随着有关NO的深入研究,NO与肿瘤生物学的关系以及NO在肿瘤免疫中的作用亦受到关注。Mφ部分抗肿瘤效应便与其分泌的NO有关。 1 一氧化氮合酶在肿瘤组织中的表达一氧化氮合酶(nitric oxide synthase, NOS)在哺乳动物细胞中有广泛表达。对肿瘤组织的NOS研究显示,不少肿瘤细胞中均存在NOS。如结肠腺癌、神经细胞瘤、鳞状细胞
NO is a simple and unstable free radical gas. Many cells have enzymes that synthesize NO. Since the 1980s, they began to understand the biological effects of NO. More than 10 years of research showed that NO can be used as a medium, messenger or cell function. Regulatory factors participate in many physiological and pathological processes in the body. Along with the in-depth study of NO, the relationship between NO and tumor biology and the role of NO in tumor immunity have also received attention. Mφ partial anti-tumor effect is related to its secretion of NO. 1 Nitric oxide synthase expression in tumor tissues Nitric oxide synthase (NOS) is widely expressed in mammalian cells. Studies of NOS in tumor tissues have revealed that many tumor cells have NOS. Such as colon adenocarcinoma, neuroblastoma, squamous cell