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目的研究红细胞与内皮细胞粘附特性在颈动脉粥样硬化、脑梗塞中的作用。方法采用流室系统，定量研究２６例脑梗塞、１１例颈动脉粥样硬化患者及１１名健康者红细胞与内皮细胞粘附特性。结果脑梗塞患者红细胞与内皮细胞粘附数目比对照组明显增高（Ｐ＜０．０１），增高程度与梗塞灶大小及神经功能缺损程度正相关；颈动脉粥样硬化患者红细胞与内皮细胞粘附比对照组高，但较脑梗塞患者低（Ｐ＜０．０１）。结论红细胞与内皮细胞粘附增强在缺血性卒中发病及脑缺血／再灌注损伤中可能发挥重要作用。
Objective To study the role of erythrocyte and endothelial cell adhesion in carotid atherosclerosis and cerebral infarction. Methods Flow chamber system was used to quantitatively study the adhesion characteristics of erythrocytes and endothelial cells in 26 patients with cerebral infarction, 11 patients with carotid atherosclerosis and 11 healthy controls. Results The number of erythrocyte and endothelial cell adhesion in cerebral infarction patients was significantly higher than that in the control group (P <0.01), and the degree of infarction was positively correlated with the infarct size and the degree of neurological deficits. The adhesion of erythrocytes to endothelial cells in patients with carotid atherosclerosis Higher than the control group, but lower than the cerebral infarction patients (P <0.01). Conclusion The enhanced adhesion between erythrocytes and endothelial cells may play an important role in the pathogenesis of ischemic stroke and cerebral ischemia / reperfusion injury.