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目的:探讨同步新辅助放化疗联合全根治切除术治疗中低位局部进展期直肠癌的临床疗效。方法:对我院2013年1月至2015年1月期间收治的78例中低位局部进展期直肠癌患者的临床资料进行回顾性分析,将入组的患者根据随机原则分为对照组和研究组,每组39例,对照组患者行全根治切除术后同步辅助放化疗,研究组患者行术前同步新辅助放化疗再行全根治切除术治疗,比较两组患者的临床治疗效果。结果:研究组患者同步新辅助放化疗后TNM分期明显降低,随访后两组患者的根治率比较无显著性差异(P>0.05),但研究组患者的复发率、保肛率及生存率显著优于对照组,手术并发症发生率显著低于对照组,两组比较差异有统计学意义(P<0.05)。结论:同步新辅助放化疗能有效提高中低位局部进展期直肠癌患者全根治切除术效果,提高患者的生存率,减少复发,值得临床进行应用及推广。
Objective: To investigate the clinical efficacy of concurrent neoadjuvant chemoradiation and total radical resection in the treatment of middle and low grade locally advanced rectal cancer. Methods: The clinical data of 78 patients with locally advanced rectal cancer in our hospital from January 2013 to January 2015 were retrospectively analyzed. According to the randomized principle, the patients were divided into control group and study group , 39 cases in each group. Patients in the control group received concurrent chemoradiotherapy after radical gastrectomy. Patients in the study group were treated with neoadjuvant radiochemotherapy before radical gastrectomy, and the clinical effects of the two groups were compared. Results: The TNM staging was significantly lower in the study group than that in the neoadjuvant chemoradiation chemotherapy group. There was no significant difference in the cure rate between the two groups after follow-up (P> 0.05). However, the recurrence rate, anus retention rate and survival rate were significantly higher in the study group Comparing with the control group, the incidence of complications was significantly lower than that of the control group. There was significant difference between the two groups (P <0.05). Conclusions: Simultaneous neoadjuvant chemoradiotherapy can effectively improve the effect of radical gastrectomy in patients with locally advanced rectal cancer at low and middle stages, improve the survival rate and reduce the recurrence rate in patients with locally advanced rectal cancer, which is worthy of clinical application and promotion.