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目的 研究特发性血小板减少性紫癜 (ITP)患儿血清中免疫球蛋白 (Ig)和T细胞亚群及可溶性白细胞介素 2受体 (sIL - 2R)的动态变化及临床意义。方法 采用比浊法和抗体致敏红细胞花环试验等方法测定了82例ITP患儿血清Ig和T细胞亚群、sIL - 2R的变化。 结果 ITP患儿CD3 ,CD4 及其CD4 /CD8值明显低于对照组及恢复期 (P <0 .0 1) ,IgG ,IgM ,CD8明显高于对照组及恢复期 ,sIL - 2R水平较对照组明显增高 (P <0 .0 1)。治疗后随着血小板上升 ,恢复期CD3 ,CD4 ,CD4 /CD8值增高。IgG ,IgM ,CD8逐渐下降到正常水平。结论 细胞免疫和体液免疫功能参与了ITP发病过程。IgG ,IgM ,CD4 /CD8比值与疾病的预后有关。
Objective To study the dynamic changes and clinical significance of serum immunoglobulin (Ig), T lymphocyte subsets and soluble interleukin 2 receptor (sIL - 2R) in children with idiopathic thrombocytopenic purpura (ITP). Methods Serum Ig and T cell subsets and sIL - 2R in 82 ITP children were measured by turbidimetric method and antibody - sensitized erythrocyte rosette test. Results The levels of CD3, CD4 and CD4 / CD8 in children with ITP were significantly lower than those in control group and convalescence group (P <0.01). The levels of IgG, IgM and CD8 in ITP children were significantly higher than those in control group and convalescence group Group was significantly higher (P <0. 01). After treatment, the platelets increased, the recovery of CD3, CD4, CD4 / CD8 increased. IgG, IgM, CD8 gradually decreased to normal levels. Conclusions Cellular immunity and humoral immune function are involved in the pathogenesis of ITP. IgG, IgM, CD4 / CD8 ratio and the prognosis of the disease.