本研究证实在牙本质龋坏组织中,存在有能使紧密交联的牙本质胶原蛋白分解的特异性胶原水解酶的活性。其来源有两种可能:(1)侵入牙本质中的龋原性细菌;(2) 牙本质自身胶原复合体中的胶原酶。牙本质龋中胶原水解酶的作用速率较为缓慢,而且牙本质胶原的分解发生于牙本质脱矿之后,说明牙本质龋的形成是首先有细菌产酸脱矿发生,尔后才有有机基质的分解破坏。 This study demonstrates the presence of specific collagen hydrolase activity in dentine carious tissues that can degrade closely cross-linked dentin collagen. There are two possible sources: (1) cariogenic bacteria that invade dentin; (2) collagenase in the dentin self-collagen complex. The effect of collagen hydrolase in dentin caries is relatively slow, and the decomposition of dentin collagen occurs after the demineralization of dentin, indicating that the formation of dentin caries is the first occurrence of bacteria acid-producing ore demineralization, and only then decomposition of the organic matrix damage.