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目的观察乌拉地尔对围术期高血压的降压作用。方法选择气管内插管全麻高血压患者18例,ASAⅡ~Ⅲ级,15例有冠状动脉供血不足,8例伴有心脏Ⅰ~Ⅱ度房室传导阻滞,肝肾功能正常,麻醉诱导用咪达唑仑0.04mg/kg,芬太尼4μg/kg,丙泊酚2.0 mg/kg和顺式苯黄酸阿曲库铵0.15 mg/kg,快速诱导气管内插管后开始手术,选择在气管内插管即刻或手术开始后血压升高超过基础值20%以上并持续3 min无下降的10例为研究对象,即从大静脉内注射乌拉地尔0.5 mg/kg,观察用药后的收缩压、舒张压、平均动脉压的变化。结果 1~3 min收缩压、舒张压、平均动脉压下降明显,作用的最高峰在10 min左右。结论围术期高血压乌拉地尔作为降压的首选药在临床上可安全应用。
Objective To observe the antihypertensive effect of urapidil on perioperative hypertension. Methods 18 cases of endotracheal intubation hypertensive patients, ASA Ⅱ ~ Ⅲ grade, 15 cases of coronary insufficiency, 8 cases with cardiac Ⅰ ~ Ⅱ degree atrioventricular block, liver and kidney function, induction of anesthesia Midazolam 0.04 mg / kg, fentanyl 4 μg / kg, propofol 2.0 mg / kg and atracurium cis-0.15 mg / kg were administered rapidly after induction of endotracheal intubation, 10 cases whose blood pressure increased more than 20% after the intubation was started or the operation started more than 3% of the baseline value without any decrease for 3 min were enrolled, that is, 0.5 mg / kg of urapidil was injected into the large intravenous injection. The systolic pressure , Diastolic blood pressure, mean arterial pressure changes. Results Systolic blood pressure, diastolic blood pressure and mean arterial blood pressure decreased obviously after 1 ~ 3 min, and the peak of the effect was about 10 min. Conclusions Urapidil as a preferred antihypertensive drug in perioperative hypertension is clinically safe.