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目的研究血管扩张剂及β受体阻滞剂联合应用在治疗肝硬化合并门脉高压中的疗效。方法 30例肝硬化合并门脉高压患者采用血管扩张剂及β受体阻滞剂联合应用治疗门脉高压,30例患者单独应用β受体阻滞剂治疗肝硬化合并门脉高压,对比观察1 a的再出血率。结果两种药物联合应用的再出血率明显低于单独应用β受体阻滞剂(P<0.05)。结论两种药物联合应用更可降低肝硬化门脉高压食管曲张静脉破裂再出血的危险性,还可减少β受体阻滞剂的应用剂量,对于有肝昏迷倾向,低血容量,低基础心率等应慎用β受体阻滞剂的患者尤其适用。
Objective To study the curative effect of combination of vasodilators and β-blockers in the treatment of liver cirrhosis complicated with portal hypertension. Methods Thirty patients with cirrhosis and portal hypertension were treated with vasodilators and β-blockers in combination with portal hypertension. Thirty patients with β-blockers alone were used to treat cirrhosis with portal hypertension. a re-bleeding rate. Results The rebleeding rate of the combination of the two drugs was significantly lower than that of β blockers alone (P <0.05). Conclusion The combination of the two drugs can reduce the risk of portal hypertension in patients with rupture of esophageal variceal bleeding, but also reduce the dose of β-blocker, for liver coma tendency, hypovolemia, low basal heart rate Such as β-blockers should be used with caution especially for patients.