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已有报告产生α亚基的垂体肿瘤或为单纯分泌α-亚基的肿瘤或伴有其他垂体激素的过量分泌。多数TSH分泌肿瘤患者血浆中α亚基的浓度升高。促性腺激素也为糖蛋白,由α及β亚基组成。新近发现在4例患促性腺激素腺瘤的患者,血浆α亚基水平升高。本文观察了整体条件下,患者对各种刺激的促性腺激素和α亚基反应,并在2例患者,用免疫组织化学检测Δα亚基的含量。4例48～68岁垂体促性腺素分泌腺瘤男性患者,有视野改变及血浆促性腺激素水平变化。另选7例19～73岁因患原发性性腺功能衰竭血浆LH及FSH水平升高的患者作为LHRH兴奋试验对照组。LHRH兴奋试验系于静脉注射100μgLHRH之前以及注射后30、60和90分钟取血。于2例行睾
Pituitary tumors that produce the alpha subunit have been reported or tumors secreted as alpha-subunit alone or with excessive secretion of other pituitary hormones. The majority of TSH-secreting tumor patients have elevated plasma concentrations of the alpha subunit. Gonadotropins are also glycoproteins, composed of alpha and beta subunits. Recently, 4 patients with gonadotroph adenoma were found to have elevated levels of plasma alpha subunit. In this study, we observed the response of various stimulated gonadotrophins and α subunits under the whole condition, and in 2 patients, the content of Δα subunit was detected by immunohistochemistry. 4 cases of 48 to 68-year-old male gonadotropin-secreting adenoma male patients with visual field changes and changes in plasma levels of gonadotropin. Another 7 patients aged 19-73 years with primary hypogonadal plasma LH and elevated levels of FSH as LHRH excitement test control group. The LHRH excitement trial bleeds blood before intravenous injection of 100 μg of LHRH and at 30, 60 and 90 minutes after injection. 2 cases of testicular