异体肾移植通常需要用类固醇和硫唑嘌呤作长期免疫抑制治疗,迄今尚未解决的问题是如何使用激素才能达到长期有效而又无并发症。本文建议对移植后肾功能已稳定了6～9个月的病人采用隔日20～30mg(接近0.25mg/kg)的疗法。病人的选择以及用药的具体方法:25例肾移植中有15例接受无亲缘关系的尸体肾。初期均应用了大剂量硫唑嘌呤和类固醇治疗,以后将硫唑嘌呤迅速减到每天2mg/kg左右,强的松逐步减到每晨单次剂量30mg(0.5mg/kg/天)。当病人在肾移植后已稳定了6个月未发生排斥反应,或虽发生过1次排斥反应,但已9个月未出现新的或有排斥活动的证据时,就开始将类固醇转为隔日用药,以5～7个月的时间完成此一转变。具体作法是每2周调整1次剂量,即紧邻的2天 Allogeneic kidney transplantation usually requires long-term immunosuppressive therapy with steroids and azathioprine, so far the unsolved problem is how to use hormones in order to achieve long-term and effective without complications. This article suggests that patients who have been stable for 6 to 9 months after transplantation have a 20-30 mg (nearly 0.25 mg / kg) therapy on alternate days. Patient selection and medication specific methods: 15 of 25 renal transplant recipients received unrelated cadaveric kidneys. Early application of high-dose azathioprine and steroid treatment, after azathioprine rapidly reduced to about 2mg / kg per day, prednisone gradually reduced to a single dose of 30mg (0.5mg / kg / day). When the patient did not have any rejection after 6 months of stable renal transplantation or had a rejection but had no evidence of new or excluded activity at 9 months, the steroid was switched to another day Medication, to 5 to 7 months to complete this change. The specific practice is to adjust the dose every 2 weeks, that is, the next 2 days