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胸腺内由骨髓衍生的前体细胞向免疫活性T 淋巴细胞发育分化的机制还远未阐明。大多数胸腺细胞同时表达CD4和CD8分子,但有关这些分子的功能以及它们与CD4~+8~+双阳性胸腺细胞的反应性也知之甚少。本文作者发现CD4可能参与影响T 细胞受体(TCR)在发育中的胸腺细胞的表达。
The mechanism by which bone marrow-derived precursor cells differentiate to immunocompetent T lymphocytes in the thymus is far from elucidated. Most thymocytes express both CD4 and CD8 molecules, but little is known about the function of these molecules and their reactivity with CD4 + + double positive thymocytes. The authors found that CD4 may be involved in affecting the expression of T-cell receptors (TCRs) in developing thymocytes.