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本文观察了500～3000rad、局部照射后一年内骨髓中CFU-S数的变化动态,同时了解造血微环境支持造血的功能之演变过程。实验发现,500rad照射后局部骨髓中CFU-S含量明显减少,恢复不稳定,同时造血微环境支持造血的功能亦有相类似的波形起伏的损伤修复过程。1000rad局部照射的骨髓中CFU-S有更显著的降低,恢复缓慢而不稳定,造血微环境支持造血的功能早期明显受损,以后虽有修复但不能恢复到正常水平。2000rad以上的X线照射可导致局部骨髓长期再生不良,造血微环境亦见剧烈而持久的功能缺陷,这一结果表明:局部照射后,屏蔽区正常造血干细胞不能在照射部位骨髓中正常种植增殖,其原因与局部造血微环境的功能障碍密切相关。
This article observed 500 ~ 3000rad, one year after local irradiation CFU-S number changes in the dynamics of the bone marrow, while understanding the hematopoietic microenvironment supporting the evolution of hematopoietic function. It was found that the CFU-S content in the local bone marrow after 500rad irradiation was significantly reduced and instability was restored. Meanwhile, the function of hematopoietic microenvironment supporting hematopoiesis was also similar to that of undulating injury repair. CFU-S in the bone marrow irradiated by 1000rad was more significantly reduced and recovered slowly and instability, and the function of hematopoietic microenvironment supporting hematopoietic cells was obviously damaged in the early stage, and after that, although repaired, it could not return to normal level. Radiofrequency more than 2000rad can lead to long-term local bone marrow regeneration failure, hematopoietic micro-environment also see the dramatic and lasting functional defects, the results show that: local irradiation normal hematopoietic stem cells in the irradiated part of the normal proliferation of bone marrow, The reason is closely related to dysfunction of local hematopoietic microenvironment.