论文部分内容阅读
目的:探究螺内酯联合美托洛尔缓释片治疗老年慢性心力衰竭(CHF)患者的临床疗效,并分析其对左室心功能的影响。方法:选择2012年2月至2015年5月期间我院收治的老年CHF患者87例,将其随机分为研究组和对照组,研究组45例,对照组42例。对照组采用常规药物治疗方式,研究组在对照组基础上采用螺内酯联合美托洛尔缓释片治疗,疗程共12周。对比两组患者的临床疗效及治疗前后的左心室功能变化。结果:研究组患者总有效率为91.11%,对照组为69.05%,组间差异有统计学意义(P<0.05);治疗后研究组LVEF高于治疗前,LVEDV、LVESV低于治疗前,且改善程度明显优于对照组,差异均有统计学意义(P<0.05)。结论:螺内酯联合美托洛尔缓释片能够显著改善老年CHF患者的左室重构和心脏功能,疗效显著,可在临床上推广使用。
Objective: To investigate the clinical efficacy of spironolactone combined with metoprolol sustained-release tablets in the treatment of elderly patients with chronic heart failure (CHF) and to analyze its effect on left ventricular cardiac function. Methods: A total of 87 elderly CHF patients admitted to our hospital from February 2012 to May 2015 were randomly divided into study group and control group, 45 cases in study group and 42 cases in control group. Control group using conventional drug treatment, the study group in the control group based on the use of spironolactone combined with metoprolol sustained-release tablets treatment, a total of 12 weeks. The clinical efficacy and changes of left ventricular function before and after treatment were compared between the two groups. Results: The total effective rate was 91.11% in the study group and 69.05% in the control group, with significant difference between the two groups (P <0.05). After treatment, the LVEF in study group was higher than that before treatment, LVEDV and LVESV were lower than before treatment The improvement was significantly better than the control group, the difference was statistically significant (P <0.05). Conclusion: Spironolactone combined with metoprolol sustained-release tablets can significantly improve left ventricular remodeling and cardiac function in elderly patients with CHF, the curative effect is significant and can be widely used clinically.