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肝素类多糖具有多种生物活性,可提供广泛的临床应用,故此类生化药物愈来愈受到人们的重视。然而普通商品肝素的强抗凝血作用给临床用药带来很多不便,限制了其它活性的应用。肝素类多糖的高度不均一性和可分性这一特点启发了人们用不同的方法分离寻找具有特异活性的肝素组分,用于不同疾病的防治。近年来国内外对肝素类多糖研究的重要方面之一,就是在结构与功能关系研究的基础上,通
Heparin polysaccharides with a variety of biological activity, can provide a wide range of clinical applications, so more and more biochemical drugs of this kind have been valued by people. However, the strong anticoagulant effect of common commercial heparin brings a lot of inconvenience to clinical medication, which limits the application of other activities. Heparin polysaccharide highly heterogeneity and separability of this feature inspired the separation of different ways to find a specific activity of heparin components for the prevention and treatment of different diseases. In recent years, one of the most important aspects of the research on heparin polysaccharide at home and abroad is based on the study of the relationship between structure and function,