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目的:探讨奥拉西坦联合尼莫地平对自发性蛛网膜下腔出血患者血清胰岛素样生长因子-1(Insulin like growth factor-1,IGF-1)、可溶性细胞间黏附分子-1(Soluble intercellular adhesion molecule-1,s ICAM-1)及可溶性血管间内皮细胞黏附分子-1(Soluble vascular adhesion molecule-1,s VCAM-1)水平的影响。方法:选取我院收治的自发性蛛网膜下腔出血患者46例,随机分配为实验组与对照组,每组23例。对照组患者给予尼莫地平治疗,实验组在对照组的治疗基础上加用奥拉西坦。比较治疗前后两组患者血清IGF-1、s ICAM-1及s VCAM-1水平,同时比较治疗结束后两组患者的临床总有效率。结果:与治疗前相比,两组患者治疗后血清IGF-1水平升高,s ICAM-1及s VCAM-1水平降低(P<0.05);且与对照组相比,实验组患者血清IGF-1水平较高,s ICAM-1及s VCAM-1水平较低,临床总有效率较高(P<0.05)。结论:奥拉西坦联合尼莫地平能够提高自发性蛛网膜下腔出血患者的临床疗效,其机制与提高患者血清IGF-1水平,降低s ICAM-1及s VCAM-1水平有关。
Objective: To investigate the effect of oxiracetam combined with nimodipine on the expression of insulin-like growth factor-1 (IGF-1), soluble intercellular adhesion molecule-1 (Soluble intercellular adhesion molecule-1) in patients with spontaneous subarachnoid hemorrhage adhesion molecule-1, s ICAM-1 and soluble vascular adhesion molecule-1 (s VCAM-1) Methods: Forty-six patients with spontaneous subarachnoid hemorrhage admitted in our hospital were randomly divided into experimental group and control group, with 23 cases in each group. Patients in the control group were treated with nimodipine, and the experimental group was given oxiracetam on the basis of the treatment of the control group. The levels of serum IGF-1, s ICAM-1 and s VCAM-1 in two groups before and after treatment were compared, and the total effective rate in both groups after the treatment was compared. Results: Compared with those before treatment, the levels of serum IGF-1, s ICAM-1 and s VCAM-1 in both groups were significantly decreased after treatment (P <0.05). Compared with the control group, serum IGF -1 levels, s ICAM-1 and s VCAM-1 levels lower, the total effective rate of clinical (P <0.05). Conclusion: Oxiracetam combined with nimodipine can improve the clinical efficacy of patients with spontaneous subarachnoid hemorrhage. Its mechanism is related to increasing serum IGF-1 level and decreasing s ICAM-1 and s VCAM-1 levels in patients with spontaneous subarachnoid hemorrhage.