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目的了解血栓素受体拮抗剂S18886对ApeE-/-小鼠颈总动脉粥样硬化斑块炎细胞浸润和形态学的影响。方法制作不破坏内弹力板的环包颈总脉模型,分别每天灌喂S188865mg/kg·b.w.、氯吡格雷25mg/kg·b.w.和空白水6周。结果应用S18886药物小鼠的右颈总动脉内膜损伤面积明显被抑制,内膜/中膜比值小于对照组和氯吡格雷组(P<0.05);内膜/总血管壁面积比值也明显低于对照组和氯吡格雷组(P<0.05);S18886组小鼠斑块部位细胞间粘连分子-1(ICAM-1)水平和巨噬细胞的浸润明显降低;对照组动脉斑块内的α-平滑肌肌动蛋白显著减低,S18886和氯吡格雷组斑块内的α-平滑肌肌动蛋白明显减低。结论血栓素受体拮抗剂S18886通过减低ICAM-1,抑制斑块部位的炎细胞浸润,回缩并稳定动脉粥样硬化斑块。
Objective To investigate the effect of thromboxane A receptor antagonist S18886 on infiltration and morphology of carotid atherosclerotic plaque in ApeE - / - mice. Methods The model of ring-necked total neck vein without destroying the inner elastic plate was made. S188865mg / kg · b · w., 25mg / kg · b · w. And 6 days of blank water were infused daily. Results The area of intima of right common carotid artery in S18886-treated mice was significantly inhibited, and the intima / media ratio was smaller than that in control group and clopidogrel group (P <0.05). The ratio of intima / total vessel wall area was also significantly lower In control group and clopidogrel group (P <0.05). The level of ICAM-1 and the infiltration of macrophages in plaque site of S18886 group were significantly decreased. The α - Smooth muscle actin was significantly reduced, S18886 and clopidogrel plaque significantly reduced α-smooth muscle actin. Conclusion S18886, a thromboxane receptor antagonist, inhibits ICAM-1 and inhibits the infiltration of inflammatory cells in the plaque site to reduce and stabilize atherosclerotic plaque.