论文部分内容阅读
目的 在离体大鼠灌注心脏模型中观察氨吡酮对布比卡因 (BU P)心脏毒性作用的影响。方法 选用 SD大鼠离体心脏 L angendorff灌注模型 ,随机将大鼠心脏分为三组 ,分别为对照组(组 )、输注 Bup 80μg/ min 15 min(组 )、输注 Bup 80μg/ m in 15 min后 ,输注氨吡酮 80μg/ m in 15 min(组 ) ,观察心率 (HR)、左室舒张末期压 (L VEDP)、左室发展压 (L VDP)、+dp/ dt、- dp/ dt的变化以及心肌 c AMP含量。结果 组 、组 在输注 Bup后 HR,L VDP、+dp/ dt、- dp/ dt值与基础值比较均明显降低 ,而 L VEDP则明显高于基础值 ,而组 在输注氨吡酮后上述指标均得以恢复 ,组 心肌c AMP含量也明显低于组 和组 。结论 氨吡酮逆转 Bup心脏毒性作用可能与其增加心肌组织c AMP含量和改善心肌收缩舒张功能有关。
Objective To observe the effects of amrinoptin on the cardiotoxicity of bupivacaine (BU P) in isolated rat heart model. Methods The Langendorff perfusion model of SD rat isolated heart was used. The hearts of rats were randomly divided into three groups: control group (group), Bup 80μg / min for 15 min (group), Bup 80μg / m in Fifteen minutes after infusion of amrinone 80 μg / m in 15 min, HR, L VEDP, L VDP, + dp / dt, Changes in dp / dt and cAMP content in myocardium. Results Compared with the baseline values, the values of HR, L VDP, + dp / dt and - dp / dt in the group and the group after the Bupn infusion were significantly decreased, while the values of L VEDP were significantly higher than those in the baseline. After the above indicators were restored, myocardial c AMP content was significantly lower than the group and group. CONCLUSION: The reversal effect of ginaton on cardiotoxicity of Bup may be related to increasing c AMP content and improving myocardial contractile and diastolic function.