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本文用两个半池组成的扩散池测定4～6周无毛小鼠腹部皮肤用1-十二烷基氮杂环庚烷2酮(Azone)预处理24h后,对抗病毒药2′,3′-双乙酰阿糖腺苷(2′,3′-di-O-acetyl-3-βD arabinofuranosyl adenine简称Ara ADA)透过皮肤促进作用的持续效应。皮肤经Azone处理后,立即或分别测定经历4,5…8d后的穿透系数。结果表明,经Azone处理后的无毛小鼠皮肤可使Ara ADA的穿透系数提高44倍,皮肤经Azone处理一次后,药物透过皮肤的促进作用至少可持续8d,药物通过皮肤的扩散时滞明显缩短。
In this paper, a diffusion cell consisting of two half-cells was used to measure the skin of the abdomen of 4 ~ 6 weeks old hairless mice after 24 hours pre-treatment with 1-dodecylazacycloheptane 2 ketone (Azone) ’- - Sustained effects of 2’, 3’-di-O-acetyl-3-βD arabinofuranosyl adenine (Ara ADA) on skin penetration. After the skin was treated with Azone, the penetration coefficients after 4,5 ... 8 days were measured immediately or separately. The results showed that the hairless skin of Azone treated mice could increase the penetration coefficient of Ara ADA by 44-fold. After the skin was treated with Azone, the promotion effect of the drug through the skin can last at least 8 days. When the drug passed through the skin, Obviously shortened.