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目的 探讨早期应用β受体阻滞剂对中重度颅脑损伤患者心肌的保护作用.方法 选取我院2014G1-2016G5入院时CKGMB、c TIn值异常的中重度颅脑损伤患者62例,根据患者入院后是否使用β受体阻滞剂,分为用药组和对照组,每组31例患者,检测两组患者入院时、入院后1d、7d及1个月CKGMB、c TIn表达改变.结果 1两组患者入院时CKGMB、c TIn表达较正常值增高,而两组之间无明显差异(P>005);2两组患者CKGMB、c TIn表达在入院后1d、7d及1个月均呈现下降趋势,且用药组CKGMB、c TIn表达水平明显低于对照组(P<005).结论 β受体阻滞剂对中重度颅脑损伤患者心肌损害具有明显的保护作用.
Objective To investigate the protective effect of early application of β-blocker on myocardial injury in patients with moderate and severe traumatic brain injury.Methods Sixty-two patients with moderate-severe traumatic brain injury with CKGMB and cTIn abnormalities at hospital admission 2014G1-2016G5 were selected according to their admission The patients were divided into medication group and control group, with 31 patients in each group.The changes of CKGMB and cTIn expression at 1d, 7d and 1 month after admission were detected.Results1 The expression of CKGMB and cTIn in group 2 were significantly higher than those in normal group (P> 0.05). 2 The expression of CKGMB and cTIn in both groups decreased after 1, 7 and 1 month after admission (P <0.05) .Conclusion β-blockers have a significant protective effect on myocardial damage in patients with moderate and severe traumatic brain injury.