肾脏中的各种前列腺素参与多种生理和病理的代谢过程,而其在肾循环中的主要功能是一种代偿机制以促进血管扩张,特别在由于血管收缩激素、血容量减少和肾脏疾病而使肾的灌注受损时。肝硬化腹水患者在用非甾体抗炎药物时,前列腺素系统被阻断,肾血流迅速减少,同时肌酐清除、钠的排泄及尿量亦明显减少,临床上与肝肾综合征极为相似。因此,起初曾有人提出肝肾综合征系前列腺素不足所致,但以后的研究发现腹水患 Various prostaglandins in the kidney are involved in a variety of physiological and pathological metabolic processes, and their primary function in the renal circulation is a compensatory mechanism to promote vasodilatation, particularly in the absence of vasoconstriction, hypovolemia and kidney disease Leaving renal perfusion damaged. Cirrhosis patients with non-steroidal anti-inflammatory drugs in the anti-inflammatory drugs, the prostaglandin system is blocked, rapid reduction of renal blood flow, while creatinine clearance, sodium excretion and urine output also significantly reduced clinically very similar to hepatorenal syndrome . Therefore, at first it was suggested that hepatorenal syndrome caused by inadequate prostaglandin, but later studies found that ascites