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为评估超声导引经皮注射乙酸（ＰＡＩ）治疗肝脏肿瘤的可行性，向１０只正常兔肝内经皮注射５０％乙酸，采用经皮注射无水乙醇作对照，观察病理变化及血清谷丙转氨酶（ＡｌＴ）的动态变化；另向３７只大鼠肝内直接注射不同剂量的５０％乙酸或乙醇，比较坏死区的大小。结果显示，与乙醇相比，乙酸注射局部组织坏死较完全且范围较大，周围组织修复较早且ＡｌＴ的峰值较低。根据电镜结果推断，乙酸造成细胞坏死的机理可能是通过固定蛋白质及直接破坏细胞膜性结构。因此，ＰＡＩ可能是一种可行的治疗方法。
To assess the feasibility of ultrasound-guided percutaneous injection of acetic acid (PAI) in the treatment of liver tumors, 10 normal rabbits were injected intradermally with 50% acetic acid and percutaneous ethanol injection was used as a control to observe pathological changes and serum glutamic-pyruvic transaminase. (AlT) dynamic changes; another 37 rats were injected intrahepatically with different doses of 50% acetic acid or ethanol, comparing the size of the necrotic area. The results showed that compared with ethanol, local tissue necrosis of acetic acid injection was more complete and the range was larger. The surrounding tissue was repaired earlier and the peak of AlT was lower. According to the results of electron microscopy, the mechanism of acetic acid-induced cell necrosis may be by immobilizing proteins and directly destroying cell membrane structures. Therefore, PAI may be a feasible treatment.