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目的探讨慢性阻塞性肺病急性发作期(AECOPD)诱导痰液中白细胞介素-8(IL-8)及白细胞介素-16(IL-16)的变化。方法AECOPD诱导痰液中IL-8及IL-16水平的检测采用酶联免疫吸附法(ELISA),并与正常人进行对照。结果AECOPD患者诱导痰液中IL-8及IL-16水平明显高于正常对照组的水平(P<0.001),AECOPD患者诱导痰液中IL-8水平与FEV1呈负相关(r=-0.73,P<0.05),IL-16水平也与FEV1呈负相关(r=-0.54,P<0.05)。结论IL-8及IL-16均参与了AECOPD的气管炎症发病过程,其中IL-8所起作用可能更重要。
Objective To investigate the changes of interleukin-8 (IL-8) and interleukin-16 (IL-16) in sputum induced by acute episode of chronic obstructive pulmonary disease (AECOPD). Methods The levels of IL-8 and IL-16 in sputum induced by AECOPD were detected by enzyme linked immunosorbent assay (ELISA) and compared with normal controls. Results The levels of IL-8 and IL-16 in induced sputum of AECOPD patients were significantly higher than those in normal controls (P <0.001). The levels of IL-8 in induced sputum of AECOPD patients were negatively correlated with FEV1 (r = -0.73, P <0.05). The level of IL-16 was also negatively correlated with FEV1 (r = -0.54, P <0.05). Conclusion Both IL-8 and IL-16 are involved in the pathogenesis of tracheal inflammation in AECOPD, and the role of IL-8 may be more important.