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在把与急性心肌梗死(AMI)相关的随机临床试验(RCT)结果外延到AMI的总体人群中时需要谨慎。因为参加AMI临床试验的患者基线危险性和住院死亡率低于未入RCT的患者,甚至低于符合入选条件的患者。法国学者Steg等选择了入组GRACE注册研究连续的8469例心肌梗死患者,分入3组,RCT参加者
Care should be taken when extending the results of a randomized clinical trial (RCT) associated with acute myocardial infarction (AMI) to the overall AMI population. Because patients participating in AMI clinical trials had lower baseline and hospital mortality rates than patients not enrolled in RCT, even below those eligible for enrollment. The French scholar Steg et al selected 8469 consecutive patients with myocardial infarction who were enrolled in the GRACE registry and were divided into three groups. The RCT participants