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对50例麻风病人横纹肌的活检进行了组织病理变化的研究。其中瘤型者40例,非瘤型者10例。所有活检材料均取自看来尚属正常的二头肌的中份。病理切片分为纵向和横向两种,以苏木素—伊红染色。并经特殊染色法处理,如:马孙氏三色法,马洛里氏磷钨酸苏木索,萋一尼抗酸染色等。形成最常见的病理损害,是位于内肌束膜、外肌束膜、肌纤维和神经周围的局性或融合性麻风瘤,有此损害的,占全部病例的34%,且多见于瘤型病人。在麻风瘤内可以找到抗酸杆菌。这些结节甚至可见于年青人者,随着年龄的增长而增多。有3例非瘤型病人显示肉芽肿病变。其他病变如横纹消失,透明性变、脂肪性变、肌纤维病变,以及伴随的内肌束膜增厚、肌肉坏死和纤维化等,都有不同程度的表现。于是有这样的推测:麻风的菌血症是杆菌侵入肌肉的途径,从而引致麻风结节的产生和退行性病变的出现。
The biopsy of striated muscle of 50 patients with leprosy was studied histopathologically. Among them, 40 cases were tumor type and 10 were non-tumor type. All biopsy material was taken from a mid-section of biceps that appears to be normal. Pathological section is divided into two kinds of vertical and horizontal to hematoxylin-eosin staining. And by special staining methods, such as: Matsussus trichrome method, Mallory’s phosphotungstic acid somato-silkworm Sui a nylon acid-fast staining. The formation of the most common pathological damage is located in the endometriosis, outer muscle bundle, muscle fibers and nerves around the local or fusion of leprosy, with this damage, accounting for 34% of all cases, and more common in patients with tumor . Acid-fast bacilli can be found in leprosy. These nodules can even be seen in young people, increasing with age. Three non-neoplastic patients showed granulomatous lesions. Other lesions such as the disappearance of stripes, translucency, fatty changes, muscle fiber lesions, and accompanying endothelium membrane thickening, muscle necrosis and fibrosis, etc., have varying degrees of performance. So there is such speculation: leprosy bacteremia Bacillus invade the muscles of the way, leading to the emergence of leprosy nodules and the emergence of degenerative diseases.