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已知肾脏对低分子量(LMW)蛋白质与多肽的分解代谢起重要作用。胃蛋白酶原(PG)是由胃粘膜合成的 LMW 蛋白质,它包括 PGA(43500±700dalt)和 PGC(40500±900dalt),两者均自循环经肾脏排泄。健康人尿中可发现大量的 PGA,但几乎没有 PGC,这是否由于肾小管的重吸收作用不同所致。本文旨在研究胃蛋白酶原在人肾脏中的代谢。9名研究对象中男7名,女2名,年龄39～65岁。常规进行冠心病的心导管检查,将两根导管分别置于腹主动脉和右肾静脉,在清晨空腹时采集肝素化
It is known that the kidney plays an important role in the catabolism of low molecular weight (LMW) proteins and polypeptides. Pepsinogen (PG) is a LMW protein synthesized by the gastric mucosa that includes PGA (43500 ± 700 dalt) and PGC (40500 ± 900 dalt), both of which are self-circulated and excreted by the kidneys. A large number of PGA can be found in healthy human urine, but there is almost no PGC, which is due to different reabsorption of renal tubules. This article aims to study the metabolism of pepsinogen in human kidneys. Nine subjects in the male 7, female 2, aged 39 to 65 years. Cardiac catheterization routine coronary heart disease, the two catheters were placed in the abdominal aorta and right renal vein, fasting in the early collection of heparin