本课题用L-精氨酸、N-乙酰精氨酸、本甲酰精氨酸对正常血田及原发性高血压大鼠离体动脉血管的舒张作用进行了研究。结果发现：三者对于两种血管平滑肌均有程度不等的舒张作用，且该舒张作用显示出剂量依赖性和内皮依赖性。药效动力学分析表明，舒张血管的半数有效浓度约在10－7mol／L范围，最大舒张效应为8％～39％左右。提示L-精氨酸及其行生物对于血压的调节及高血压的治疗有一定的作用。 The subject of L-arginine, N-acetyl arginine, this formyl arginine normal blood and essential hypertension in isolated rat arterial vasodilatation was studied. The results showed that: the three have varying degrees of relaxation on both vascular smooth muscle, and the diastolic effect showed a dose-dependent and endothelium-dependent. Pharmacodynamic analysis showed that the effective concentration of diastolic blood vessels in the range of about 10-7mol / L, the maximum relaxation effect of about 8% to 39%. It is suggested that L-arginine and its derivatives have a certain effect on the regulation of blood pressure and the treatment of hypertension.