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目的观察枫蓼肠胃康片联合奥美拉唑和复方嗜酸乳杆菌治疗急性胃肠炎的临床疗效。方法选取2015年2月—2016年2月在建始县中医院接受治疗的急性胃肠炎患者94例,随机分为对照组和治疗组,每组各47例。两组患者均给予急性胃肠炎的对症治疗。对照组口服奥美拉唑肠溶片,20 mg/次,1次/d;同时口服复方嗜酸乳杆菌片,1 g/次,3次/d。治疗组在对照组的基础上口服枫蓼肠胃康片,4片/次,3次/d。两组患者均连续治疗2周。观察两组的临床疗效,同时比较治疗前后两组的临床症状评分,以及血清降钙素(PCT)、白细胞介素-6(IL-6)和IL-8的水平变化。结果治疗后,对照组的总有效率为82.98%,治疗组为95.74%,两组总有效率比较差异具有统计学意义(P<0.05)。两组的临床症状评分和总积分均较治疗前显著降低(P<0.05),且与对照组相比,治疗组降低更为明显,两组比较差异具有统计学意义(P<0.05)。两组PCT、IL-6、IL-8水平均较治疗前明显下降(P<0.05),且治疗组的血清学指标水平较对照组下降的更为明显(P<0.05)。结论枫蓼肠胃康片联合奥美拉唑和复方嗜酸乳杆菌治疗急性胃肠炎疗效显著,可明显改善患者临床症状,减轻机体炎症反应,具有一定的临床推广应用价值。
Objective To observe the curative effect of Fengliao Changweikang Tablets combined with omeprazole and compound Lactobacillus acidophilus in the treatment of acute gastroenteritis. Methods 94 patients with acute gastroenteritis treated in Jianshi Chinese Medicine Hospital from February 2015 to February 2016 were randomly divided into control group and treatment group, with 47 cases in each group. Two groups of patients were given symptomatic treatment of acute gastroenteritis. The control group orally administered omeprazole enteric-coated tablets, 20 mg / time, 1 / d; oral compound acidophilus Lactobacillus tablets, 1 g / time, 3 times / d. The treatment group on the basis of the control group oral Fengliao Chang Wei Kang tablets, 4 tablets / time, 3 times / d. Two groups of patients were treated for 2 weeks. The clinical efficacy of the two groups were observed. The clinical symptom scores, serum PCT, IL-6 and IL-8 levels were compared between the two groups before and after treatment. Results After treatment, the total effective rate of the control group was 82.98%, the treatment group was 95.74%, the total effective rate was statistically significant difference (P <0.05). The scores of clinical symptoms and the total scores of both groups were significantly lower than those before treatment (P <0.05). Compared with the control group, the scores of the clinical symptoms and the total scores of the two groups decreased more obviously. The difference between the two groups was statistically significant (P <0.05). The levels of PCT, IL-6 and IL-8 in both groups were significantly lower than those before treatment (P <0.05), and the serological parameters of the two groups were significantly lower than those of the control group (P <0.05). Conclusion Fengliao Changweicang tablets combined with omeprazole and compound acidophilus Lactobacillus treatment of acute gastroenteritis significant effect, can significantly improve the clinical symptoms and reduce the body inflammatory response, with a certain clinical application value.