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目的探讨麝香保心丸长期治疗对冠心病患者心血管事件及消化道出血的影响。方法选择2011年5月—2012年5月我院收治的冠心病患者120例,将其随机分为治疗组和对照组,各60例。对照组给予常规西药治疗,治疗组在常规西药治疗的基础上口服麝香保心丸,疗程均为12个月。电话随访1年,记录患者心血管事件和消化道出血发生情况。结果随访1年,治疗组心血管事件发生率为11.7%,低于对照组的21.7%(P<0.05);消化道出血发生率为11.7%,与对照组的8.3%比较,差异无统计学意义(P>0.05)。结论长期口服麝香保心丸能有效预防冠心病患者心血管事件的发生,同时不增加消化道出血风险。
Objective To investigate the effect of long-term treatment with Shexiang Baoxin Pill on cardiovascular events and gastrointestinal bleeding in patients with coronary heart disease. Methods From May 2011 to May 2012, 120 patients with coronary heart disease admitted to our hospital were randomly divided into treatment group and control group, with 60 cases in each. The control group was given conventional western medicine. The treatment group was given oral musk heart pill on the basis of conventional Western medicine for 12 months. The phone was followed up for 1 year and recorded the occurrence of cardiovascular events and gastrointestinal bleeding in patients. Results The follow-up of one year showed that the incidence of cardiovascular events in the treatment group was 11.7%, lower than that in the control group (21.7%, P <0.05). The incidence of gastrointestinal bleeding was 11.7%, which was not statistically different from that in the control group Significance (P> 0.05). Conclusion Long-term oral administration of Shexiang Baoxin Pill can effectively prevent the occurrence of cardiovascular events in patients with coronary heart disease without increasing the risk of gastrointestinal bleeding.