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目的研究β族胸腺素在乳腺癌及癌旁组织中的表达。方法采用免疫组织化学染色方法检测β族胸腺素在乳腺癌组织中的表达。结果Tβ4、Tβ10、Tβ15蛋白在乳腺癌的癌细胞质中呈弥漫表达,三者在乳腺癌组织中的表达与癌旁乳腺组织的表达差异有显著性(P<0.01)。三者在乳腺癌中的蛋白表达差异无显著性,在有淋巴结转移及无淋巴结转移的乳腺癌中的蛋白表达差异有显著性(P<0.05)。结论Tβ4、Tβ10、Tβ15蛋白表达与乳腺癌的淋巴结转移呈正相关,与乳腺癌的年龄、乳腺癌的组织分型无相关性。
Objective To study the expression of β thymosin in breast cancer and its adjacent tissues. Methods Immunohistochemical staining was used to detect the expression of β thymosin in breast cancer. Results The expressions of Tβ4, Tβ10 and Tβ15 were diffusely expressed in the cytoplasm of breast cancer. The expressions of Tβ4, Tβ10 and Tβ15 in breast cancer tissues were significantly different from those in adjacent noncancerous tissues (P <0.01). There was no significant difference in the expression of these three proteins in breast cancer. The protein expression in breast cancer with lymph node metastasis and without lymph node metastasis was significantly different (P <0.05). Conclusion The expressions of Tβ4, Tβ10 and Tβ15 are positively correlated with the lymph node metastasis of breast cancer and have no correlation with the age of breast cancer and the histological type of breast cancer.