据Medsger和Masi(1971)大规模调查结果,每百万人中硬皮病的年新发病人数为2.7。至于矽肺合并硬皮病的问题,意见不尽一致,Erasmus(1960)报告南非金矿工人中硬皮病的发病率相当高,但Rogan(1960)声称英国金矿中几乎没有见到一例。据Makapehko N.N.归纳,到1963年为止报告的矽肺合并硬皮病的病例在15例以上。而Rodnan等(1967)认为煤矿工人、石工以及患尘肺的陶瓷和铸造工人中, According to large-scale surveys by Medsger and Masi (1971), the annual number of new cases of scleroderma per million people is 2.7. With regard to silicosis associated with scleroderma, there is mixed opinion. Erasmus (1960) reported a very high incidence of scleroderma in gold miners in South Africa, but Rogan (1960) claimed that few were found in the UK gold mine. According to Makapehko N.N., there were more than 15 cases of silicosis and scleroderma reported by 1963. Rodnan et al. (1967) found that among coal miners, masonry, and porcelain and foundry workers suffering from pneumoconiosis,