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HPV和CIN与癌有关。下生殖道HPV感染发生率近年明显增多,有可能是最常见的性传播疾病。本研究涉及的妇女为首次巴氏涂片异常,阴道镜下宫颈存在遇酸变白损害但无CIN组织学特点。100例巴氏涂片异常病人中,130次阴道镜检确认有宫颈遇酸变白病损取活检。其中60份(47%)诊断C INⅠ,11份(7%)诊断为CINⅡ～CINⅢ,59份未诊断为CIN。对这59份用Southern印迹杂交法分析HPV DNA序列。其中20份(34%)检出HPV DNA。其HPV类型分布为:HPV6/11(3),HP V16(6)、HPV31(1),以及与HPV有关
HPV and CIN are related to cancer. The incidence of genital HPV infection in recent years increased significantly, may be the most common sexually transmitted diseases. The women involved in this study were first-time Pap smear abnormalities. Cervical lesions under the colposcopy were found to have acid whitening lesions but no CIN histological features. Of the 100 patients with Pap smear abnormalities, 130 colposcopy confirmed the presence of cervical acid lesions and lesions of the lesion biopsy. Of these, 60 (47%) diagnosed C IN I, 11 (7%) diagnosed as CIN II to CIN III and 59 were not diagnosed as CIN. The 59 samples were analyzed for HPV DNA sequence by Southern blot hybridization. Twenty (34%) detected HPV DNA. The distribution of HPV types: HPV6 / 11 (3), HP V16 (6), HPV31 (1), and HPV-related