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吲哚美辛在碱性溶液中不稳定,可发生专属性碱催化水解。鉴于吲哚美辛在三(羟甲基)氨基甲烷缓冲液中的降解速率加快,作者用HPLC 的方法研究了该药在不同的氨基醇
Indomethacin is unstable in alkaline solution and can undergo specific base-catalyzed hydrolysis. In view of the accelerated degradation rate of indomethacin in tris (hydroxymethyl) aminomethane buffer, the authors used HPLC method to study the drug in different amino alcohols