对新合成的一系列嘧啶酮衍生物,进行了诱导小鼠血清干扰素活性实验。结果表明:凡是2-氨基-5-溴-6-取代-4(3H)嘧啶酮结构的化合物都是活性较强的干扰素诱导剂,其它取代形式则无效或活性降低。新合成的6-对磺酸苯基衍生物,有较高的水溶性,但诱生血清干扰能力降低。所有新合成的化合物诱导干扰素能力都不及 ABPP. A series of newly synthesized pyrimidinone derivatives were tested for their activity in inducing mouse serum interferon. The results showed that all the compounds with 2-amino-5-bromo-6-substituted-4 (3H) pyrimidinone structures were active interferon inducing agents, and the other substituted forms were inactive or with reduced activity. The newly synthesized phenyl derivatives of 6-p-sulfonic acid have higher water solubility, but lower the ability to induce serum interference. All new synthetic compounds have less ability to induce interferon than ABPP.