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盐酸纳洛酮为阿片受体纯拮抗剂,能与阿片受体产生特异性结合,其亲合力大于吗啡和脑啡肽,故能迅速翻转吗啡和哌替啶的作用,作用较烯丙吗啡强7～10倍。当以麻醉镇痛药为主的静脉复合麻醉病人出现呼吸抑制时,盐酸纳洛酮iv 1～3 min,即可解除呼吸抑制,增加呼吸频率和通气量。在临床使用中对非麻醉性药物(酒精、安定等)急性中毒、休克、急性呼吸衰竭和脑梗塞等亦有较好的治疗效果。它也是研究阿片受体、内源性阿片样物质和镇痛药作用机理的工具药。
Naloxone Hydrochloride is a pure antagonist of opioid receptors, can produce specific binding with opioid receptors, its affinity is greater than that of morphine and enkephalin, it can quickly turn over the role of morphine and pethidine, compared with the effect of morphine 7 to 10 times. When the narcotic analgesic-based intravenous anesthesia patients with respiratory depression, naloxone hydrochloride iv 1 ~ 3 min, you can lift the respiratory depression, increased respiratory rate and ventilation. In clinical use of non-narcotic drugs (alcohol, stability, etc.) acute poisoning, shock, acute respiratory failure and cerebral infarction also have better therapeutic effect. It is also a tool to study the mechanisms of action of opioid receptors, endogenous opioids and analgesics.